芬兰儿童创伤性脑损伤和后来的精神病综合征
Juho Laaksonen1, Ville Ponkilainen2, Julius Möttönen3
1Department of Clinical Medicine, University of Tampere, Tampere, Finland. juho.laaksonen@tuni.fi.
European journal of pediatrics
|May 31, 2025
概括
儿科创伤性脑损伤 (pTBI) 与精神病综合征的风险略微增加,长达10年. 患有pTBI的女性患者患上这些疾病的风险明显更高.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 儿科创伤性脑损伤 (pTBI) 和随后的精神病综合征之间的联系尚不清楚,现有的研究主要集中在精神分裂症上.
- 这项研究解决了这一差距,通过在全国范围的队列中调查pTBI和精神病综合征之间的关联.
研究的目的:
- 评估儿科创伤性脑损伤 (pTBI) 与创伤后精神病综合征的发生率之间的关联.
- 分析长期风险,并确定影响这种关联的任何特定人口因素.
主要方法:
- 芬兰从1998年到2018年进行了一项全国性的回顾性队列研究.
- 包括71,969名患有TBI的儿科患者 (18岁以下) 和64,856名患有远端四肢骨折的对照.
- 用卡普兰-梅尔生存分析和多变量考克斯回归来分析精神病综合征的发生.
主要成果:
- 儿童TBI患者表现出持续增加的精神病综合征率,特别是在受伤后的10年.
- 精神病综合征的累积发病率在pTBI组为0.04%,在第一年之后的参考组为0.02%.
- 长期分析显示,pTBI的风险增加,危险比为1.34 (95% CI: 1.16-1.55) 长达10年. 患有pTBI的女性患者在前3年内表现出明显更高的风险 (HR 2.00,95% CI: 1.24-3.23).
结论:
- 患上精神病综合征的风险在儿童创伤性脑损伤 (pTBI) 后的10年内仍然略高.
- 与男性和普通人群相比,经历pTBI的女性患者面临着更高的创伤后精神病综合征风险.
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