分析多发性硬化症患者下泌尿道症状的出现情况
Jan Krhut1,2, Pavel Hradílek3,4, Adéla Kondé5,6
1Department of Urology, University Hospital, Tř. 17. listopadu 1790, Ostrava, 708 52, Czech Republic. jan.krhut@fno.cz.
World journal of urology
|May 31, 2025
概括
多发性硬化症患者的下尿路症状 (LUTS) 通常在诊断后8年出现,紧急是最常见的初始症状. 较高的年龄和残疾增加了LUTS早期发病的风险.
科学领域:
- 神经学 神经学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 临床研究 临床研究
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经疾病,影响中枢神经系统.
- 下泌尿道症状 (LUTS) 是MS (PwMS) 患者常见的,经常使人衰弱的并发症.
- 了解PwMS中LUTS的时间发病和风险因素对于及时干预和管理至关重要.
研究的目的:
- 为了确定MS诊断后LUTS发病的平均时间.
- 为了确定哪种特定类型的LUTS通常在PwMS中首先表现出来.
- 确定与该人群中LUTS早期发展相关的风险因素.
主要方法:
- 一项涉及1167个符合麦当劳标准的PwMS的观察性研究 (2017).
- 数据收集包括结构化的面对面采访和与医疗记录的交叉验证.
- 参与者的平均年龄为45岁,病期平均为11年.
主要成果:
- 在MS诊断后,LUTS发病的中位时间为8年.
- 储存症状,特别是紧急情况 (51%) 是最常见的最初报告的LUTS.
- 诊断时的较高年龄,增加的残疾和小脑/金字塔症状与较早的LUTS发作有关.
结论:
- 在MS诊断后大约8年,LUTS通常会发展.
- 紧迫性是PwMS体验的主要初始下尿路症状.
- 诸如晚年和在诊断时的神经障碍等因素预测LUTS的早期发病.
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