影响非洲儿童头部伤害死亡风险的因素:元分析
Kwadwo Darko1, Bernice Limann2, Pearl Ohenewaa Tenkorang3
1Department of Neurosurgery, Korle Bu Teaching Hospital, Accra, Ghana.
概括
道路交通事故 (RTA) 和发作是低收入和中等收入国家儿童头部伤害死亡率的关键风险因素. 早期预防措施,如改善基础设施,可以降低儿科TBI死亡率.
科学领域:
- 全球健康 全球健康
- 儿科创伤学 儿科创伤学
- 流行病学 流行病学
背景情况:
- 与高收入国家相比,低收入和中等收入国家 (LMICs) 的创伤性脑损伤 (TBI) 死亡率明显高于高收入国家.
- 儿科头部伤害在LMIC中是一个重大的公共卫生问题,需要对死亡风险因素有更深入的了解.
研究的目的:
- 系统地审查和评估影响LMIC中头部受伤儿科患者死亡风险的因素.
- 确定与儿科TBI病例死亡率增加相关的特定原因和临床表现.
主要方法:
- 根据PRISMA指南进行了全面的系统审查.
- 在PubMed,Google Scholar和Web of Science数据库中进行了文献搜索.
- 分析了来自12个非洲国家的42项研究的数据.
主要成果:
- 这项研究包括来自12个非洲国家的42项研究,分析了儿童头部伤害.
- 道路交通事故 (RTA) 是造成伤害的主要原因 (56.0-69.2%),其次是跌倒 (21.0-37.9%).
- 总体死亡率为19%,RTA被确定为一个重要的风险因素 (RR:43.7).
结论:
- 在报告中,公路交通事故和发作被确定为儿童头部伤害死亡率的关键风险因素.
- 建议实施早期预防策略,包括改善道路安全基础设施,以减轻儿科TBI死亡率.
更多相关视频
09:49Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
3.6K
07:30A Test Bed to Examine Helmet Fit and Retention and Biomechanical Measures of Head and Neck Injury in Simulated Impact
Published on: September 21, 2017
9.3K
相关概念视频
Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Pharmacokinetics in Pediatric Patients: Drug Distribution
258
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
258
Pharmacokinetics in Pediatric Patients: Drug Metabolism
195
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
195
Pharmacokinetics in Pediatric Patients: Drug Excretion
214
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
