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早期皮质变化和神经心理机制在肌缩侧面硬化症中的神经心理机制

Qianqian Zhang¹, Yu Ding¹, Yu Zhang¹

¹Department of Rare Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, China.

NeuroImage. Clinical

|May 31, 2025

概括

肌肉皮层变化在肌缩侧面硬化症 (ALS) 影响情绪和认知功能. 这些变化可以作为早期诊断生物标志物,提供有关疾病机制的见解.

科学领域:

神经科学是一个神经科学.
神经学神经学
医疗成像医学成像

背景情况:

肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病,影响运动神经元.
在ALS患者中,认知和情绪功能障碍越来越被认可.
早期诊断和了解疾病机制对于患者管理至关重要.

研究的目的:

研究ALS患者皮质结构和功能变化的研究.
检查这些变化如何调节情绪和认知功能.
评估这些皮质变化的诊断价值在早期的ALS.

主要方法:

多参数MRI,神经心理评估和血清神经丝光链 (NfL) 水平在59名ALS患者和31名对照组中使用.
调解分析探索了皮质改变对情绪和认知功能的影响.
支持矢量机 (SVM) 模型评估了皮质参数的诊断效用.

主要成果:

关节病患者表现出 cingulate 和前腔区域的皮质厚度和功能活性增加,与神经心理性能和NfL水平相关.
特定区域的功能活动调解了抑郁症状与认知功能之间的关系.
使用变化的区域和低频波动幅度 (ALFF) 的SVM模型显示了中等的诊断性能 (AUC=0.853).

结论:

在ALS中皮质结构和功能变化在抑郁症对认知功能的影响中起着调解作用.
这些发现为ALS的神经心理机制提供了洞察力.
改变的皮层区域显示出作为早期ALS诊断的生物标志物的潜力.

关键词:

骨髓缩侧面硬化症 (ALS) 是一种大脑皮层大脑皮层认知能力认知能力认知能力抑郁症抑郁症抑郁症磁共振成像是一种磁共振成像技术.

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