孕产妇周产期抑郁症和后代注意力缺陷和多动性障碍的风险:一项链接数据研究
Biruk Shalmeno Tusa1, Rosa Alati2, Kim Betts3
1School of Population Health, Curtin University, Perth, WA, Australia; Department of Epidemiology and Biostatistics, College of Health and Medical Sciences, Haramaya University, Haramaya, Ethiopia.
孕产妇产前抑郁症显著增加后代注意力缺陷/多动症 (ADHD) 的风险. 诸如早产等不良分娩结果在这种关联中发挥的作用很小,这凸显了母亲心理健康支持的重要性.
科学领域:
- 围产期心理健康研究
- 儿童发育障碍 儿童发育障碍
- 流行病学 流行病学
背景情况:
- 孕产妇产周抑郁症是一个越来越令人担忧的问题.
- 母亲抑郁症和后代注意力缺陷/多动障碍 (ADHD) 之间的联系需要进一步调查.
- 了解不良分娩结果在这种关联中的作用至关重要.
研究的目的:
- 为了检查患有围产期抑郁症的母亲的后代患有ADHD的风险.
- 调查直接和间接的途径,包括不利的出生结果,将母亲的抑郁症与后代的ADHD联系起来.
- 评估低出生体重,低Apgar分数和早产的调解效应.
主要方法:
- 使用行政相关健康数据的回顾性队列研究.
- 使用ICD-10-AM代码识别的孕产妇周产期抑郁症和后代ADHD.
- 用了通用线性模型和调解分析来评估关联和调解效应.
主要成果:
- 患有产前,产后和产周抑郁症的母亲的后代显示ADHD风险明显增加 (ORs从1.80到2.16不等).
- 过早分娩对产前抑郁症和多动症之间的关联进行了最小的调解 (0.73%的总影响).
- 低出生体重和低Apgar分数并没有调解母亲抑郁症和后代ADHD之间的关系.
结论:
- 孕产妇产周抑郁症与子女多动症的风险增加独立相关.
- 不利的出生结果对母亲抑郁症和后代多动症之间的关系的影响很小,甚至没有中介作用.
- 优先考虑对母亲心理健康的早期干预对于降低儿童ADHD风险至关重要.
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