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基于废水的流感病毒流行病学:系统性审查
Luca Viviani1, Riccardo Vecchio1, Elena Pariani2
1PhD National Programme in One Health approaches to infectious diseases and life science research, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
The Science of the total environment
|May 31, 2025
概括
基于废水的流行病学 (WBE) 显示了监测社区流感病毒 (IVs) 的潜力. 需要进一步的研究来完善方法,并将WBE数据整合到流感监测的公共卫生战略中.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生监督是对公共卫生的监督.
- 病毒学 病毒学
背景情况:
- 基于废水的流行病学 (WBE) 是监测病原体循环的越来越多的工具,包括流感病毒 (IVs).
- 流感监测依赖于准确和及时的数据,以告知公共卫生干预.
研究的目的:
- 系统地审查和总结有关WBE在流感监测方面的现有证据.
- 使用WBE绘制流感监测活动的地图,评估病毒恢复方法,探索与临床数据的联系,并评估IV亚型的可行性.
主要方法:
- 按照PRISMA指南进行了系统审查.
- 研究通过对PubMed/Medline,Scopus和Web of Science数据库的全面搜索来确定这些研究.
- 分析包括了42个原始数据研究.
主要成果:
- 在大多数审查的研究中检测到流感病毒,尽管通常度低于SARS-CoV-2.
- 废水固体分数通常比液体超水剂更好地检测了IV.
- 研究探讨了环境病毒载荷和临床数据之间的联系,以及废水中的IV亚型,结果各不相同.
结论:
- WBE对监测人类和动物群体的流感循环具有前景,为疫情规模和循环亚型提供了洞察力.
- 实验技术和协议的标准化对于可靠的WBE数据至关重要.
- 将WBE发现纳入公共卫生战略需要进一步的研究和开发.
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