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在绝经后乳腺癌患者中评估化疗诱导的外周神经病变,使用振动感知值.

August Nielsen1, Simone Diedrichsen Marstrand1, Djordje Marina1,2

  • 1Department of Nephrology and Endocrinology, Rigshospitalet, Copenhagen, Denmark.

Cancer investigation
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概括

早期乳腺癌患者的化疗诱导的周围神经病变 (CIPN) 在3年后显示振动感知值 (VPT) 测量正常化. 然而,主观生活质量评分没有显著改善,突出了评估CIPN.的局限性.

关键词:
乳腺癌 乳腺癌 乳腺癌化疗诱导的周围神经病变EORTC QLQ-CIPN20 QLQ-CIPN20 EORTC QLQ-CIPN20 QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 EORTC QLQ-CIPN20 CIPN20 CIPN20 CIPN20 CIPN20 CIPN20 CIPN20敏感度指数是指敏感度指数.感知振动的门值.

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科学领域:

  • 在瘤学瘤学.
  • 神经科学是一个神经科学.
  • 临床试验 临床试验

背景情况:

  • 化疗诱导的周围神经病变 (CIPN) 是早期乳腺癌 (EBC) 患者常见的剂量限制性副作用.
  • 了解CIPN的长期发展和客观/主观评估对于患者管理至关重要.

研究的目的:

  • 研究患有EBC的绝经后妇女中CIPN的3年发展.
  • 评估振动感知值 (VPT) 测量和欧洲癌症研究和治疗组织生活质量调查问卷 (CIPN18) 进行CIPN评估.

主要方法:

  • 展望性研究涉及90名EBC患者 (50-70岁) 和30名健康对照.
  • 在化疗后进行的VPT测量和CIPN18问卷,以及12个月和36个月的随访.
  • 统计分析包括斯皮尔曼的rho和通用添加模型.

主要成果:

  • 与对照组相比,VPT测量在化疗后受损,但在36个月后正常化.
  • 平均CIPN18分数有所改善,但不具有统计学意义.
  • 在VPT和CIPN18之间观察到弱至中度的相关性,高级建模没有证实有意义的相关性.

结论:

  • 在EBC患者中,VPT测量可能会在3年内正常化,这表明自发恢复的可能性.
  • 主观生活质量评分 (CIPN18) 没有显著改善,这表明患者报告的结果可能存在脱节.
  • 在将客观的VPT测量与主观的CIPN18分数相对应方面存在局限性,尽管VPT作为客观评估工具具有前景.