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Updated: Sep 19, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

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在表观遗传上准PRMT5通过诱导内源逆转录病毒的表达和触发病毒模仿反应来促进抗瘤免疫力

Hua Zhang1, Gang Shi2, Yamei Li3

  • 1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Pathology, General Hospital of Western Theater Command, Chengdu, 610083, China; Pancreatic Injury and Repair Key Laboratory of Sichuan Province, General Hospital of Western Theater Command, Chengdu, 610083, China.

Translational research : the journal of laboratory and clinical medicine
|May 31, 2025
PubMed
概括

在结肠直肠癌 (CRC) 中抑制PRMT5会触发病毒模仿反应,增强免疫检查点阻塞 (ICB) 疗法. 这种表观遗传方法通过重新激活先天免疫信号通路来提高抗瘤免疫力.

关键词:
结肠直肠癌是一种癌症.内生逆转录病毒是内生逆转录病毒.免疫检查站封锁免疫检查站封锁天生的传感器是天生的传感器在PRMT5中,我们使用了PRMT5.瘤的免疫微环境病毒模仿病毒的模仿.

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