相关实验视频

Updated: Jun 16, 2025

Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain

Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain

Published on: July 18, 2016

绘制疼痛路径:VPL-S1HL-ACC电路在中枢中风后疼痛中的作用

Panyang Li¹, Chaofan Lu², Mingliang Wang³

¹Department of Human Anatomy, Histology and Embryology, Faculty of Basic Medicine, Henan Medical College, No.8 Shuanghu Avenue, Zhengzhou 451191, China.

Brain research bulletin

|May 31, 2025

概括

中央中风后疼痛 (CPSP) 涉及特定的神经回路. 在小鼠中激活VPL-S1HL-ACC通路会引起疼痛,而抑制它会减少疼痛,提供治疗见解.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
神经学神经学

背景情况:

中心中风后疼痛 (CPSP) 是一种使人衰弱的慢性神经病症.
中央敏感化是推动CPSP和不良临床结果的关键机制.
神经回路对于调节慢性疼痛状态至关重要.

研究的目的:

阐明潜在的中枢中风后疼痛 (CPSP) 的特定神经电路机制.
确定关键的大脑区域和参与CPSP病变的途径.
探索潜在的治疗目标来管理CPSP.

主要方法:

使用内原酶注射建立了CPSP的小鼠模型.
利用cFos免疫光和体内成像来识别激活核.
使用病毒追踪,光遗传学,化学遗传学和行为分析来绘制和操纵神经回路.

主要成果:

确定了一条关键电路,涉及腹部后侧膜核 (VPL),主要体感皮质 (S1HL) 和前带膜皮质 (ACC).
在CPSP小鼠中观察到ipsilateral S1HL和ACC神经元的强烈激活.
证明激活S1HL-ACC神经元诱导疼痛行为,而抑制缓解疼痛;特定电路激活模仿疼痛症状.

结论:

VPL-S1HL-ACC神经回路在调解与CPSP相关的疼痛异常方面发挥着关键作用.
这些发现为CPSP中中央敏感化机制提供了新的见解.
这种电路代表了对CPSP管理的有希望的治疗目标.

关键词:

在 ACC ACC ACC ACC ACC ACC ACC ACC ACC ACC ACC 中心敏感化中心疼痛疼痛疼痛疼痛在S1HLHL中使用.一次性中风,中风.在VPL VPL的基础上.

更多相关视频

$Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain$ 09:35

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

相关概念视频

Vascular Spasm

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...

Nociception

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.

Major Somatic Sensory Pathways

Major Somatic Sensory Pathways

Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...