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在视神经头部的细胞.

Susannah Waxman1, Deborah Villafranca-Baughman2, Julie Phillippi3

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概括

对于微血管系统至关重要的细胞在视神经头部 (ONH) 发现,可能在青光眼中发挥作用. 对ONH细胞的进一步研究可能会导致新的青光眼治疗方法.

关键词:
血液的流动 血液的流动眼光障碍 眼光障碍 眼光障碍 眼光障碍视神经的头部 视神经的头部危险细胞 (Pericyte) 是一种危险细胞.

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科学领域:

  • 眼科医生 眼科 眼科
  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学

背景情况:

  • 细胞是收缩性壁细胞,对微血管功能至关重要,调节血液流动并维持屏障.
  • 细胞功能障碍与神经退行性疾病有关,但它们在视神经头部 (ONH) 中的作用尚不清楚.
  • ONH是格洛瘤神经退行早期的部位,强调了研究局部细胞周细胞贡献的必要性.

研究的目的:

  • 总结当前关于ONH生理学和玻璃眼瘤中的危细胞作用的知识.
  • 为了研究皮质细胞的存在和潜在功能在健康和眼ONH.
  • 为了确定青光眼中微血管功能障碍的治疗点.

主要方法:

  • 在ONH健康和玻璃眼病中对细胞细胞功能进行文献综述.
  • 在小鼠,非人类灵长类动物和人类ONH组织中检查皮质细胞存在的组织学检查.
  • 对因子的分析,将青光眼中的ONH功能障碍与其他神经退行性疾病中的皮质细胞功能障碍联系起来.

主要成果:

  • 在小鼠,非人类灵长类动物和人类ONH的微血管系统中发现了pericytes.
  • 与玻璃眼疾病中ONH功能障碍相关的因素显示,与其他神经退行性疾病中的细胞周细胞功能障碍有关.
  • 皮细胞的存在表明在ONH内具有局部功能的能力.

结论:

  • 在物种中存在ONH细胞体,这表明它们在微血管调节中可能发挥局部作用.
  • 细胞是一个有希望的,但尚未研究的目标,用于解决青光眼的微血管功能障碍.
  • 了解皮质细胞对健康和疾病的贡献,对于开发眼新型治疗策略至关重要.