慢性不可预测的压力会产生过敏症并促进中部前额皮层中抑制驱动
Laura Maile1, Krista Mercado2, Leena Baig2
1Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
The journal of pain
|May 31, 2025
概括
慢性压力会恶化男性小鼠的疼痛敏感性和恢复. 压力改变了前临界皮层的抑制信号,这是压力和疼痛相互作用的关键大脑区域.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 压力生物学 压力生物学
背景情况:
- 慢性压力和疼痛经常并存,使患者的结果恶化.
- 调解这种并发症的大脑区域尚未完全理解.
- 中间前额叶皮层 (mPFC) 参与压力和疼痛处理.
研究的目的:
- 研究慢性不可预测压力 (CUS) 对疼痛行为和恢复的影响.
- 检查mPFC的前临床皮层 (PL) 区域的神经生理变化.
- 在神经元层面探索压力和疼痛之间的相互作用.
主要方法:
- 一只老鼠模型的慢性不可预测的压力 (CUS).
- 评估热和机械疼痛行为,疼痛耐受性和受伤恢复.
- 电子生理学记录和前临界皮层 (PL) 神经元向腹侧周水管灰色 (vlPAG) 突出的结构分析.
主要成果:
- 在雄性小鼠中,CUS诱导疼痛过敏和疼痛耐受性降低,但不是雌性小鼠.
- 受到压力的雄性小鼠在受伤后表现出持续的疼痛和类似焦虑的行为.
- 在有害刺激后,CUS在PL皮质中降低了神经元活动 (cFos表达).
- 在受压力的小鼠中观察到对PL-vlPAG神经元的抑制驱动增加.
结论:
- 慢性压力会加剧疼痛,并影响恢复,特别是在男性中.
- 前皮质在压力下调节疼痛方面发挥着至关重要的作用.
- 压力改变了mPFC-vlPAG通路中的突触功能,导致疼痛并发症.
相关概念视频
Hypothalamic-Pituitary Axis
62.0K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
62.0K
Stress and Mental Health
221
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
221
Physiological Foundation of Stress
174
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
174
The Sympathetic Nervous System
96.8K
Overview
96.8K
Desensitization and Tachyphylaxis
2.3K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.3K
Nociception
29.5K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
29.5K


