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Updated: Sep 19, 2025

Inducing Cre-lox Recombination in Mouse Cerebral Cortex Through In Utero Electroporation
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由Tg(Crx-cre) 1T毛皮小鼠菌株诱导的基因重组模式在视觉系统器官中的表征

C Felgerolle1, E Villalonga2, A Attallah3

  • 1UMR7355, CNRS, Orléans, France; Immuno-NEuro Modulation, University of Orléans, Orléans, France.

Experimental eye research
|May 31, 2025
PubMed
概括

在Tg(Crx-cre) 1Tfur小鼠模型导致在视网膜,但也在大脑中基因重组. 研究人员应该谨慎地使用这种模型进行视网膜研究,考虑到其更广泛的重组效应.

关键词:
基因重组是基因的重组.穆林的模型模型视网膜特异性 视网膜特异性Tg ((Crx-cre) 的意思就是说.视觉系统 视觉系统

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Conservative Site-specific Recombination and Phase Variation02:53

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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