类似PXA的瘤:预后影响
Supriya Bhardwaj1, Hemlata Jangir1, Swati Singh1
1Neuropathology Laboratory, All India Institute of Medical Sciences, New Delhi, India.
概括
在儿科病例中,DNA甲基化分析揭示了多形性黄细胞瘤 (PXA),挑战了传统的分级. 这些PXA瘤表现出侵略性特征和低生存率,表明需要修订分类策略.
科学领域:
- 神经瘤学神经瘤学
- 分子病理学分子病理学
- 儿科瘤学 儿科瘤学
背景情况:
- 中枢神经系统 (CNS) 瘤分类正在随着分子标记物演变而发展.
- DNA甲基化分析提供了对瘤异质性的新见解.
研究的目的:
- 为了调查表观遗传分析,组织形态学和中枢神经系统WHO等级之间的差异.
- 根据分子分类分析儿科中枢神经系统瘤的治疗和生存结果.
主要方法:
- 对三个儿科病例 (9-15岁) 进行了回顾性分析,诊断出高度质瘤.
- 多学科评估包括组织形态学,DNA甲基化分析 (海德堡/DKFZ分类器) 和中枢神经系统WHO分级.
- 评估患者生存时间的持续时间.
主要成果:
- 组织病理学和中枢神经系统的WHO分级揭示了患有BRAF V600E突变的扩散儿科类型高度质瘤 (PHGG) 和质母细胞瘤.
- 通过DNA甲基化分析,这三种病例都被统一地归类为多形性黄细胞瘤 (PXA).
- 尽管PXA分类,但患者的平均存活率很差,为13.7个月.
结论:
- 甲基化类PXA可以包括具有侵略性基因病理特征的瘤.
- 根据甲基化分析的定义,PXA瘤可能呈现出不良的预后.
- 这凸显了将分子数据整合为准确的中枢神经系统瘤分类和预后的重要性.
相关概念视频
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
01:30Peripheral Artery Disease I: Introduction
37
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
37