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在眼睛中,Lamina cribrosa的 perfusion 密度降低,视网膜中枢静脉封闭
Matteo Menean1,2, Lorenzo Bianco3,4, Lida Perna3,4
1School of Medicine, Vita-Salute San Raffaele University, Milan, Italy. menean.matteo@hsr.it.
概括
中央视网膜静脉封闭 (CRVO) 导致膜中 perfusion 密度降低. 曲率的结构变化表明了更硬的微型架构,影响了受CRVO影响的眼睛的血液流动.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜血管疾病 视网膜血管疾病
- 眼科成像 眼科成像
背景情况:
- 中央视网膜静脉封闭 (CRVO) 是视力丧失的一个重要原因.
- 关于CRVO的确切病因和病理生理学,特别是关于状板的病理生理学,仍然不完全理解.
- 先进的成像技术对于阐明CRVO的结构和血管变化至关重要.
研究的目的:
- 在受CRVO影响的眼睛中,研究状眼膜的体内结构和血管变化.
- 为了将这些变化与健康的眼睛相比较,使用光学一致性断层扫描 (OCT) 和OCT-血管扫描 (OCTA).
主要方法:
- 这是一项回顾性,横截面研究,涉及37名CRVO患者及其健康眼睛的同伴.
- 使用结构性OCT,量化板状骨厚度,曲率深度 (CD) 和曲率指数 (CI).
- 通过面对面的OCTA测量板状晶透密度 (PD).
主要成果:
- 在CRVO和对照眼睛之间没有观察到晶片板厚度或深度的显著差异.
- 在CRVO眼中,曲率指数 (CI) 和曲率深度 (CD) 的趋势较高.
- 与对照人群相比,CRVO眼睛的晶片板中的 perfusion density (PD) 显著降低 (p < 0.001).与对照人群相比,CRVO眼睛的晶片板中的 perfusion density (PD) 显著降低 (p < 0.001).
- PD与厚度,CD,CI或眼内压力 (IOP) 没有显著的关联.
结论:
- 在体内实验中,OCT和OCTA在CRVO发作后显示出晶状体板上明显的结构和血管变化.
- 晶片板的曲变化可能表明更硬,更压缩的微型架构.
- 这些微观架构变化可能有助于观察到CRVO眼中的内在 perfusion 度量减少.
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