基于生物标志物的格雷夫斯眼病和2型糖尿病之间的关系的探索
Yu Guan1, Meng Fan2, Xiaolin Ren3
1Department of Ophthalmology, The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu, 610051, Sichuan, China.
概括
早期诊断Graves眼病 (GO) 和2型糖尿病 (T2D) 是一个挑战. 年龄,甲状腺刺激激素 (TSH),糖化血红蛋白 (HbA1c) 和葡萄糖水平有效地预测了这两种情况.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 代谢疾病 代谢疾病
背景情况:
- 格雷夫斯眼病 (GO) 的发展可能是无声的,并与2型糖尿病 (T2D) 一起发生.
- 同时存在的GO和T2D的早期诊断带来了重大的临床挑战.
- 确定可靠的生物标志物对于及时干预至关重要.
研究的目的:
- 在2型糖尿病 (T2D) 患者中确定用于早期诊断Graves眼病 (GO) 的有效生物标志物.
- 开发一种用于诊断GO和同时存在的T2D的预测模型.
主要方法:
- 评估了123名T2D和GO患者和128名GO患者.
- 测量了各种生物标志物的水平,包括甲状腺激素和血糖指标.
- 开发了一种多变量逻辑回归模型来评估诊断疗效.
主要成果:
- 高龄和高甲状腺刺激激素 (TSH),糖化血红蛋白 (HbA1c) 和禁食葡萄糖水平与GO-T2D相关.
- 一个回归模型显示了高的诊断准确性 (R=0.70,灵敏度=87.80%,特异性=93.75%,AUC=0.97).
- 在多变量分析中,自由三甲状腺素 (FT3) 和自由甲状腺素 (FT4) 水平没有保持统计学意义.
结论:
- 年龄,TSH,HbA1c和葡萄糖水平是诊断GO和T2D的有效预测因素.
- 在GO患者中对这些生物标志物的常规监测可以促进早期T2D检测.
- 在GO患者中早期诊断和治疗T2D可以改善预后.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Diabetes: Symptoms, Diagnosis, and Complications
520
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
520
Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Pathophysiology of Diabetes
908
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
908
Psychoneuroimmunology: Diabetes and Cancer
27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
Carbohydrate Metabolism
10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K


