一项多中心横截面研究,以阐明神经性厌食症中岛屿皮层改变的静止状态功能连接性,按功能局部化细分
Yusuke Sudo1,2,3, Rio Kamashita1,4, Tsunehiko Takamura5
1Research Center for Child Mental Development Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Scientific reports
|May 31, 2025
概括
神经性厌食症 (AN) 患者在胰岛中显示出大脑连接的改变,特别是背部前胰岛和杏仁体之间的休息状态功能连接 (rsFC) 增加. 这些神经变化可能解释了AN症状,例如对负面刺激的敏感性增加.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 岛屿功能与神经性厌食症 (AN) 病理生理学有关.
- 之前的研究缺乏足够的样本大小,无法在AN中进行详细的胰岛-大脑连接分析.
- 岛屿的功能定位对于准确的连接映射至关重要.
研究的目的:
- 调查安静状态的功能连接 (rsFC) 之间的insula和整个大脑在女性患者与AN.
- 在AN中识别特定的岛屿次区域及其改变的连接模式.
- 通过大脑连接探索AN症状的神经基础.
主要方法:
- 重新分析了114名女性AN患者和135名女性健康对照 (HC) 的功能磁共振成像 (fMRI) 数据.
- 将岛屿分为每侧6个功能区域 (12个种子ROI).
- 计算了岛屿ROI和142个全脑目标ROI之间的rsFC,使用FDR校正.
主要成果:
- 与HC相比,AN患者表现出背部前胰岛 (daIC) 和杏仁体之间的rsFC增加.
- AN患者在背部中部岛屿 (pdmIC) 的后部划分和骨皮层之间显示出减少的rsFC.
- 这些发现具有统计学意义 (FDR 校正 p < 0.05).
结论:
- 改变的岛屿连接,特别是桃体和骨皮质,可能是核心AN症状的基础.
- 这些rsFC变化为对负面刺激的过敏,味觉障碍和对AN的厌恶学习提供了潜在的神经基础.
- 这项研究强调了功能定义的岛屿子区域在理解AN神经生物学方面的重要性.
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