脱水二二酸对男性和女性使用孟德尔随机化的寿命的影响
C Mary Schooling1, Jie V Zhao2
1City University of New York, Graduate School of Public Health and Health Policy, New York, NY, USA; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China.
概括
脱氨硫酸 (DHEA-s) 水平随着年龄的增长而下降. 这项研究发现,DHEA-s与男性的寿命缩短有关,但与女性无关,因性别而有不同的血压关联.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
- 老年学是指老年学的学科.
背景情况:
- 脱氨 (DHEA) 和DHEA-硫酸盐 (DHEA-s) 水平随着年龄的增长而下降,并且与衰老过程有关.
- 观察性研究表明,DHEA/DHEA可能会在老年男性中延长寿命.
- 没有确定的临床试验确定了DHEA/DHEA在衰老或人类寿命中的作用.
研究的目的:
- 调查DHEA在寿命中的作用及其与关键生物决定因素的关联.
- 评估DHEA-s对血压,阿波蛋白B (ApoB) 和血红蛋白A1c (HbA1c) 的影响.
- 通过使用双样本的门德尔随机化 (MR) 方法,检查男性和女性的这些关联.
主要方法:
- 使用了两个样本的门德尔随机化 (MR) 研究设计.
- 采用遗传变异作为自然存在的DHEA-s水平的工具变量.
- 分析了来自英国大型生物库和Life-Adult/Life-Heart队伍的寿命,血压,ApoB和HbA1c关联的数据.
主要成果:
- DHEA-s与女性的寿命没有关联,但与男性的寿命缩短有关 (p=0.0017).
- 与寿命和腹筋血压的关联性在性别之间有显著差异.
- 在男性中,DHEA与静缩和静缩血压有积极的关联,与较低的ApoB有潜在的关联.
结论:
- 与女性相比,DHEA与男性的寿命和血压有明显的关联.
- 这些发现表明DHEA-s.的性别特异性生物学作用.
- 考虑可能对DHEA补充剂的潜在监管带来的公共健康益处可能是合理的.
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