维生素A缺乏症与自闭症谱系障碍儿童的光神经病变和光神经病变呈现
Ryohei Morita1, Kumiko Kato2, Ryunosuke Nagashima1
1Department of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Documenta ophthalmologica. Advances in ophthalmology
|June 1, 2025
概括
一个罕见的儿童严重的维生素A缺乏症 (VAD) 病例导致了亡,外otropia 和视力丧失. 早期诊断和补充治疗对于预防不可逆转的视神经病变至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 维生素A缺乏 (VAD) 是一个全球性的健康问题,特别是在儿童中.
- VAD可能导致严重的眼部表现,包括角膜损伤和视力受损.
- 罕见的VAD病例呈现出不寻常的症状,如ptosis和exotropia.
研究的目的:
- 为了记录一个罕见的儿科VAD病例,呈现出ptosis和exotropia.
- 要突出诊断挑战和管理的VAD在一个小孩子.
- 强调早期检测和干预对于预防长期视觉后果的重要性.
主要方法:
- 一个5岁的男孩接受了全面的眼科检查.
- 诊断工具包括全场电网膜学 (ff-ERG),光学连贯性断层扫描 (OCT) 和磁共振成像 (MRI).
- 血液测试证实了严重的VAD,详细的饮食史揭示了高度选择性的饮食习惯.
主要成果:
- 最初的表现包括严重的视力障碍 (0.02视力敏度),双侧角膜不透明,结膜角质化和外向性.
- 电生理学测试显示了灭绝的光学和减少的光学ff-ERG.
- 用口服维生素A和酸治疗导致角膜和亡症状的改善,ff-ERG的部分恢复,但在OCT和视觉唤起潜力上观察到持续的视神经病变.
结论:
- 在这个儿科病例中,VAD的延迟诊断和治疗导致了不可逆转的视神经病变.
- 早期和彻底的饮食评估对于识别异常表现的儿童的VAD至关重要.
- 及时的电生理学查和适当的补充剂对于减轻儿科VAD永久视力损伤的风险至关重要.
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