长期COVID中的肠道微生物签名:潜在的生物标志物和治疗点
Soyoung Oh1,2, Sujin An3, Kihyun Park4
1Infectious Disease Research Center, Citizen's Health Bureau, Seoul Metropolitan Government, Seoul, Republic of Korea.
Infectious diseases and therapy
|June 1, 2025
概括
长期COVID患者表现出明显的肠道微生物特征,特定的细菌如Leuconostoc和Actinomyces可能作为这种疾病的生物标志物. 这些肠道微生物组的变化与症状严重程度和代谢因素相关.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 长期冠状病毒病 (COVID) 影响超过10%的SARS-CoV-2患者,持续超过12周.
- 肠道微生物群失调与长期COVID有关,但具体关系尚不清楚.
研究的目的:
- 调查肠道微生物群组成和长期COVID严重程度之间的联系.
- 为了确定长期COVID的潜在肠道微生物组生物标志物.
主要方法:
- 来自31名长期COVID患者,14名COVID-19患者和23名健康对照的便样本的16S rRNA基因测序.
- 使用患者报告的结果评估长期COVID症状严重程度.
- 微生物特征,症状严重程度和血液生物标志物之间的相关性分析.
主要成果:
- 与对照组相比,在长期COVID患者中观察到不同的肠道微生物概况.
- 诸如Leuconostoc,Actinomyces和Granulicatella等属在长期COVID患者中被丰富,可以作为生物标志物.
- 特定的肠道细菌的丰度与症状严重程度和血液生物标志物如甘油三和葡萄糖相关.
结论:
- 长期COVID患者的肠道微生物特征与健康个体有很大的不同.
- 某些微生物种类显示出作为初步生物标志物和长期COVID的潜在治疗点的前景.
- 需要在更大的研究中进一步验证以确认这些发现.
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