相关实验视频

Updated: Sep 19, 2025

Simple and Efficient Production and Purification of Mouse Myelin Oligodendrocyte Glycoprotein for Experimental Autoimmune Encephalomyelitis Studies
10:47

Simple and Efficient Production and Purification of Mouse Myelin Oligodendrocyte Glycoprotein for Experimental Autoimmune Encephalomyelitis Studies

Published on: October 27, 2016

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通过MDA5变体保护自身免疫性疾病的分子基础

Rahul Singh1, Joe D Joiner2, Alba Herrero Del Valle3

  • 1Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.

Cell reports
|June 1, 2025
PubMed
概括

MDA5 (黑色素瘤分化相关基因5) 的自身免疫保护变异抑制其RNA传感. 一些变种会损害RNA结合或增加ATPase活性,从而降低免疫反应.

关键词:
它们是ATP酶.CP: 免疫学 免疫学类似RIG-I的受体 (RLR)这种RNA基酶是RNA基酶.感应RNA的感应RNA.自免疫性疾病突变突变.双链RNA (dsRNA) 是一种双链RNA.健身权益权益权益权益权益权益权益权衡人类遗传变异的人类遗传变异.这是先天免疫力.疾病的分子机制.

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