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Updated: Sep 19, 2025

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
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在DNA拓聚酶3A中的病理突变的功能分析

Yiqing Wang1, Sebastian Kaiser1, Javier Martin-Gonzalez2

  • 1Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark.

Cell reports
|June 1, 2025
PubMed
概括

在小鼠中,DNA拓酶IIIα (TOP3A) 突变会导致胚胎死亡和线粒体DNA损失. 对于TOP3A来说,C端域至关重要.

关键词:
科普:分子生物学 分子生物学结合 DNA 的 DNA 结合.在DNA拓学上.胚胎发育过程中的胚胎.线粒体基因组维护维护人类疾病的小鼠模型.

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