疲劳,身体功能,以及癌症老年人的社会脆弱性背景
Marielle Jensen-Battaglia1, Alan Delmerico2, Mostafa Mohamed3
1James P. Wilmot Cancer Institute, 601 Elmwood Ave, Rochester, NY 14642, United States of America; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, Rochester, NY 14642, United States of America.
Journal of geriatric oncology
|June 1, 2025
概括
老年人与癌症相关的疲劳与身体功能下降有关,无论社会脆弱性如何. 早期评估和对疲劳的管理对于这个患者群体至关重要.
科学领域:
- 老年瘤学 老年瘤学
- 癌症患者的治疗结果
- 在衰老中的身体功能.
背景情况:
- 与癌症相关的疲劳显著影响老年人的身体功能.
- 健康的社会决定因素 (SDOH) 可能会加剧与疲劳相关的身体衰退.
- 老年癌症患者经常面临多种健康挑战,包括疲劳和与衰老相关的损伤.
研究的目的:
- 调查癌症相关疲劳与晚期癌症老年人身体功能下降之间的关联.
- 探索社会脆弱性是否会改变疲劳和身体功能之间的关系.
- 确定干预管理疲劳和身体功能的关键时间点.
主要方法:
- 全国集群随机临床试验的分析,包括70岁以上的晚期癌症患者.
- 在基线和多个后续点收集疲劳严重程度 (PROC-CTCAE) 和身体功能 (短物理性能电池 - SPPB) 数据.
- 测量县级社会脆弱性指数 (SVI) 以评估社区级SDOH.
主要成果:
- 较大的基线疲劳与4-6周的身体功能下降 (SPPB) 风险增加显著相关 (RR 1.21).
- 疲劳和身体功能下降之间的这种关联在3个月或6个月后并不显着.
- 疲劳对身体功能下降的影响没有根据社会脆弱程度 (SVI) 不同.
结论:
- 与癌症相关的疲劳是晚期癌症老年人短期身体功能下降的重要预测因素.
- 社会脆弱性似乎没有改变疲劳和身体功能下降之间的关联.
- 对疲劳评估和管理的临床重点对于在这个人群中保持身体功能至关重要.
相关概念视频
01:21Fatigue
250
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
250
01:19The Effect of Aging on Tissues
2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
01:24Muscle Recovery and Fatigue
2.6K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.6K
01:30Heart Failure VII: Nursing Interventions
147
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
147
01:26Aging
198
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
198
01:22Fatigue Strength of Concrete
293
Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
293