前十字带断裂后的步态适应是性别特异性的
Kim Lefebvre1, Clémence Delestre1, Neila Mezghani2
1Laboratoire d'innovation ouverte (LIO), École de technologie supérieure, 1100 Notre-Dame Ouest, Montréal, Québec H3C 1K3, Canada.
The Knee
|June 1, 2025
概括
这项研究在前十字带缺陷 (ACLD) 患者中发现了性别特异的步态适应. 在ACLD的女性中,出现了更多的斜面和正面平面变化,而男性则出现了正面平面和部旋转适应,这表明需要性别特定的康复.
科学领域:
- 生物力学 生物力学
- 整形外科 整形外科 整形外科
- 运动医学 运动医学
背景情况:
- 在前交叉带缺陷 (ACLD) 的膝盖中,步态运动适应是常见的.
- 以前的研究还没有全面地将ACLD患者的动力学与整个步行周期的性别匹配对照进行比较.
研究的目的:
- 识别和比较ACLD患者与他们的性别匹配对照在整个步行周期中的步行动力学差异.
主要方法:
- 一个回顾性研究合并两个数据库.
- 44名男性 (ACLD-M) 和27名女性 (ACLD-F) 的膝盖步态动力与32名健康男性 (Control-M) 和37名女性 (Control-F) 的膝盖步态动力比较.
- 在跑步机上行走时使用KneeKG®系统来捕捉运动.
主要成果:
- 与对照人群相比,ACLD雄性在特定的步行阶段表现出减少的角和增加的外旋转.
- 与对照组相比,ACLD女性在大部分步行周期中表现出膝盖曲和角的增加.
结论:
- 在ACL破裂后,发生了显著的性别特异性步行适应.
- 妇女在姿势时表现出较大适应性在前平面和前平面,而男性在姿势和摆动时表现出前平面和骨旋转变化.
- ACL 损伤动力学和随后的康复策略应根据个体的性别进行调整.
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相关概念视频
X-linked Traits
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
Sex-linked Disorders
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Nondisjunction
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
X-linked Traits
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
Dosage Compensation
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
Nondisjunction
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
