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Updated: May 11, 2026

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在患有 kongenital cytomegalovirus 的儿童中,听力和神经发育结果

Jordan C Stout¹, Jessica Leung², Peter Kfoury¹

¹Department of Otolaryngology - Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.

International journal of pediatric otorhinolaryngology

|June 1, 2025

概括

先天性细胞巨乳病毒 (cCMV) 感染是儿童神经发育迟缓和听力损失的常见原因. 这项研究强调了这些结果在多元化的美国队列中到6岁的患病率.

科学领域:

儿科健康儿科健康
传染性疾病传染性疾病
发育儿科发育儿科

背景情况:

先天性细胞巨乳病毒 (cCMV) 是最常见的先天性感染,也是感觉神经听力损失的主要非遗传原因.
早期识别和监测cCMV对于管理长期健康影响至关重要.

研究的目的:

为了评估人口统计学,临床特征和神经发育结果,包括听力损失,在美国儿童可能有cCMV.在6岁以下.
分析来自大量多元群体的数据,以了解cCMV对儿童发育的影响.

主要方法:

从2006年至2019年使用听力学和遗传数据库 (AudGenDB) 的回顾性队列研究.
使用诊断码识别可能患有cCMV的儿童,分析出生后45天内临床症状和神经发育状况,直到6岁.
听力损失的定义是纯音调平均值或任何频率值≥25dB.

主要成果:

确定了180名可能患有cCMV的儿童;70%的儿童在45天后被诊断出患有cCMV.
黑人和西班牙裔/拉丁裔儿童在cCMV组中占比不大.
72%的cCMV儿童被诊断为神经发育疾病,包括听力损失 (56名儿童),沟通延迟 (45) 和脑 (22);听力损失被诊断在2岁的平均年龄.

结论:

在患有cCMV的儿童中,神经发育迟缓很普遍.
AudGenDB提供了有价值的纵向数据,用于研究大型多样化人口中的cCMV结果.
这些数据对于在没有通用国家强制性查的情况下为公共卫生战略提供信息很重要.

关键词:

遗传性细胞巨型病毒感染.听力损失,双边听力损失听力损失,单方面的听力损失.神经发育障碍神经发育障碍神经系统上的后果.儿科听力学儿科听力学感官神经神经听力损失是什么

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Cytomegalovirus Disease

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...