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富含miR166u的Polygonatum sibiricum外体样纳米颗粒通过TLR4/AKT通路改善肠道屏障来缓解大肠炎

Chaozhi Wei¹, Yue Chen², Jiali Chen³

¹Xianghu Laboratory, Hangzhou 311231, Zhejiang, China; College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China.

International journal of biological macromolecules

|June 1, 2025

概括

波利格纳 (Polygonatum sibiricum) 的外体样纳米颗粒 (PSELNs) 通过恢复肠道屏障和调节炎症,有效治疗结肠炎. 这些天然纳米载体还重塑肠道微生物群,并针对治疗益处的炎症途径.

科学领域:

纳米医学是一种纳米医学.
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

肠道炎症,特别是结肠炎,对健康构成重大挑战.
自然纳米载体提供潜在的治疗途径,但它们的机制需要阐明.
来自Polygonatum sibiricum的外体样纳米粒子 (PSELNs) 正在成为有前途的药物.

研究的目的:

评估PSELN对小鼠的硫酸 (DSS) 诱导的大肠炎的保护作用.
阐明大肠炎中PSELNs的潜在治疗机制.

主要方法:

从P. sibiricum根茎中使用触流过方法分离的PSELN.
通过电子显微镜,纳米粒子跟踪和miRNA测序进行表征.
在体内DSS诱导的大肠炎模型与口服PSELN的管理,其次是组织学,分子和微生物群的分析.

主要成果:

PSELNs显示了胃肠道稳定性和目标结肠输送.
PSELNs改善了结肠炎的严重程度,恢复了结肠结构,并增强了肠道屏障功能 (ZO-1,Occludin,MUC2).
PSELNs减少了炎症 (TNF-α,LPS),降低了TLR4/AKT/NF-κB信号传输,重新塑造了肠道微生物群 (增加了阿克尔曼西亚),并调节了新陈代谢.
在PSELN中的miR166u直接向CD11c以抑制炎症.

结论:

PSELNs代表了一种新的饮食衍生治疗大肠炎的治疗策略.
治疗效果通过肠道屏障恢复,免疫调节和微生物群-代谢物相互作用来调节.
PSELNs提供了一种有前途的天然纳米载体方法来控制肠道炎症.

关键词:

大肠炎是什么意思类似于外体的纳米纤维.肠道屏障肠道屏障肠道屏障这种植物名为Polygonatum sibiricum.这是一个小RNARNA.

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