对儿童B细胞急性淋巴细胞白血病中MLL-AF9融合基因介导的化疗耐药性的分子洞察力

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Xu Sang1, Yanchun Guan1, Mengying Jiang1

  • 1Department of Pediatrics, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China.

The Journal of biological chemistry
|June 1, 2025
PubMed
概括

患有MLL-AF9融合的儿童B细胞急性淋巴细胞白血病 (B-ALL) 通过上调IGFBP7,激活ABCB1载体和DNA修复来发展化学抵抗. 针对这些途径可以在模型中逆转阻力.

关键词:
美国ABC运输商ABC运输商IGFBP7 IGFBP7 IGFBP7 IGFBP7 IGFBP7 IGFBP7 IGFBP7 IGFBP7在MLL-AF9基因融合基因.不同类型的末端连接维修路径.儿科B细胞急性淋巴细胞白血病蛋白质组学 蛋白质组学翻译学 翻译学 翻译学 翻译学

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