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Updated: Sep 19, 2025

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转录因子HOXA9诱导染色体修饰剂SMYD3的表达,以驱动白血病发生

Liping Zhang1, Jinqiu Zhong1, Luo Yang2

  • 1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University Institute of Tumor Pharmacology, College of Pharmacy, Jinan University, Guangzhou, China.

The Journal of biological chemistry
|June 1, 2025
PubMed
概括

含有SET和MYND域的蛋白3 (SMYD3) 通过激活HOXA9转录来驱动急性髓性白血病 (AML). 在DOT1L抑制的同时针对这个SMYD3-HOXA9循环显示出治疗MLL-AF9驱动的AML的希望.

关键词:
在AML,AML就是AML.这就是HOXA9A9的意思.在MLL-AF9在SMYD3中,不同化的差异化差异化.积极的反循环是一个循环.转录激活的激活方式

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