"放射治疗中的衰老和表观遗传影响:BNCT的前景"
Chiara Papulino1, Marco Crepaldi1, Gregorio Favale1
1Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples 80138, Italy.
Ageing research reviews
|June 1, 2025
概括
放射治疗 (RT) 在选择性向瘤方面面临挑战,衰老和表观遗传学影响了耐药性. 先进的方法,如中子捕获疗法 (BNCT) 和表观遗传药物,有望改善癌症治疗结果.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 分子生物学分子生物学
背景情况:
- 传统放射治疗 (RT) 对癌症控制至关重要,但与选择性瘤细胞杀死和健康组织损伤作斗争.
- 患者的年龄和瘤特征影响RT的疗效和耐受性,老年患者通常受益于其非侵入性.
- 辐射诱导的DNA损伤可能导致细胞衰老,促进炎症,并导致健康组织损伤和瘤放射性抵抗.
研究的目的:
- 审查传统的RT机制,挑战,以及衰老对治疗的影响.
- 描述衰老和表观遗传因素在RT耐药性中的作用.
- 探索中子捕获疗法 (BNCT) 的进展以及表观遗传药物提高RT结果的潜力.
主要方法:
- 关于传统放射治疗,细胞衰老,表观遗传修饰和中子捕获疗法 (BNCT) 的文献综述.
- 分析衰老对RT疗效和患者耐受性的影响.
- 对表观遗传化合物及其在调节瘤辐射敏感性中的作用研究的审查.
主要成果:
- 细胞衰老和表观遗传改变是影响瘤抗 RT 的关键因素.
- 中子捕获疗法 (BNCT) 在特定癌症,如质母细胞瘤和头癌中表现出有效性.
- 表观遗传调制是一个潜在的策略,可以提高RT的有效性.
结论:
- 优化RT需要解决诸如衰老和表观遗传抵抗等挑战.
- 像BNCT这样的新兴技术提供了有针对性的瘤破坏,并可能减少副作用.
- 结合RT与表观遗传疗法,有望显著提高癌症治疗疗效.
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