孕妇对多种微量营养素补充剂在怀孕期间的影响的贡献:系统性审查和个人参与者数据的元分析
Emily R Smith1, Filomena Gomes2, Seth Adu-Afarwuah3
1Department of Global Health, Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States.
Advances in nutrition (Bethesda, Md.)
|June 1, 2025
概括
在怀孕期间多种微量营养素补充剂 (MMS) 显著改善婴儿出生体重,特别是在高度坚持的情况下. 与铁和叶酸 (IFA) 单独相比,对MMS的低坚持没有出生体重的好处.
科学领域:
- 孕产妇和儿童的健康
- 营养科学 营养科学
- 公共卫生干预措施 公共卫生干预
背景情况:
- 众所周知,在怀孕期间多种微量营养素补充剂 (MMS) 与单独的铁和叶酸 (IFA) 相比,可以改善母亲和婴儿的结果.
- 在现实环境中,MMS的有效性可能会受到诸如启动时间和坚持等因素的影响.
研究的目的:
- 与IFA相比,评估遵守和启动时间对MMS有效性的影响.
- 评估MMS接受者的坚持因子和母亲/婴儿结局之间的观察相关性.
主要方法:
- 一个双阶段的15个随机试验的个人参与者数据元分析,涉及61,204名孕妇.
- 与MMS有效性相关的坚持,开始时的妊娠年龄和服用的药片总数的分析.
- 在接受MMS的女性中观察性分析了坚持因子.
主要成果:
- 与IFA相比,MMS对出生体重的相对影响在较高的坚持下更大.
- 对MMS的高坚持 (≥90%) 增加了56g的出生体重;低坚持 (<60%) 与IFA没有差异.
- 较低的坚持 (<75%) 与死产和母体贫血的风险增加有关.
结论:
- 在怀孕期间高度坚持多种微量营养素补充剂 (MMS) 对于最大限度地获得改善出生体重等好处至关重要.
- 母婴健康计划应优先考虑促进早期启动和高度遵守MMS的战略.
- 专注于遵守的干预措施可以提高MMS在减少不良分娩结果方面的有效性.
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