皮细胞中的Opsin 3调解了阿托皮性皮肤炎的因光引起的夸大
Liya Mao1, Huibin Yin1, Zhuoqiong Qiu2
1Department of Dermatology, Shanghai Institute of Dermatology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
The Journal of allergy and clinical immunology
|June 1, 2025
概括
奥普辛3 (OPN3) 通过增加皮肤细胞中的炎症性细胞因子,在暴露于光线时加剧亚托皮炎 (AD) 炎症. 这种光受体可能是AD的治疗点.
科学领域:
- 皮肤病学 皮肤病学
- 摄影生物学 摄影生物学
- 分子生物学分子生物学
背景情况:
- 亚托皮炎 (AD) 是一种慢性炎症性皮肤疾病,通常因阳光照射而恶化.
- 光受体Opsin 3 (OPN3) 影响皮肤功能,但其在光引起的AD炎症中的作用尚不清楚.
研究的目的:
- 调查OPN3在光引起的AD恶化中的作用和潜在机制.
主要方法:
- 通过使用qPCR,西式涂抹,IHC和免疫光检测评估了OPN3表达.
- 在小鼠模型和角质细胞 (KCs) 中评估了光和OPN3在2型炎症中的作用.
- 通过RNA测序,ELISA,成像和免疫光学检查了OPN3机制.
主要成果:
- 在AD病变和小鼠模型中,OPN3的表达增加,但在牛皮模型中没有.
- 2型细胞因子诱导KC中的OPN3,上调IL-36γ,TNF-α,IL-8和IL-1β.
- 暴露于光线会通过OPN3介导的流和S1P信号恶化AD炎症.
结论:
- 在暴露于光线下的KC中,OPN3具有特定于微环境的益炎作用.
- OPN3对亚托皮性皮肤炎具有潜在的治疗点.
相关概念视频
Photoreceptors and Visual Pathways
6.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.5K
Channel Rhodopsins
2.6K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
2.6K
Photoreceptors and Plant Responses to Light
25.8K
Light plays a significant role in regulating the growth and development of plants. In addition to providing energy for photosynthesis, light provides other important cues to regulate a range of developmental and physiological responses in plants.
25.8K
Pigmentation
2.8K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.8K
Role of Skin in Vitamin D Synthesis
5.8K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.8K
The Retina
70.6K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
70.6K


