不同药物管理措施在老年慢性病患者和多药学中的有效性:系统性审查和网络元分析
Qi Wang1, Jiansheng Zhang2, Kunpeng Li1
1School of Medical and Health Engineering in Changzhou University, No. 21, Gehu Middle Road, Wujin District, Changzhou City, Jiangsu Province, 213164, PR China.
Research in social & administrative pharmacy : RSAP
|June 1, 2025
概括
降低处方干预 (DI) 和随访的药物审查 (MRF) 显示出改善慢性疾病的老年人药物管理的希望. 这些策略可以提高处方的适当性,生活质量,并减少住院病例.
科学领域:
- 老年学和老年医学是老年学和老年医学.
- 临床药房 临床药房
- 医疗保健服务研究 医疗服务研究
背景情况:
- 在患有慢性疾病的老年人中,多药制品存在重大管理挑战.
- 现有的研究缺乏全面的网络元分析,比较该群体的各种药物管理策略.
研究的目的:
- 进行网络元分析,评估不同药物管理措施的有效性.
- 评估这些措施对慢性病和多药的老年患者的影响.
主要方法:
- 在多个数据库 (PubMed,科学网,Embase,Cochrane图书馆,CINAHL) 进行系统搜索,截至2024年2月28日.
- 包括随机对照试验 (RCT),重点关注患有慢性疾病的老年人和多药.
- 通过网络元分析评估结果,包括药物数量,生活质量,死亡率,住院率和跌倒率.
主要成果:
- 处方干预措施 (DI) 改善了处方的适当性 (MD = -0.90).
- 随访的药物审查 (MRF) 降低了住院率 (RR = 0.26).
- DI,MRF,药物治疗咨询和教育 (CE),以及医疗电子决策支持工具 (EDS) 显示出具体结果的希望.
结论:
- DI,MRF,CE和EDS是优化老年人药物管理的有希望的策略.
- 这些干预措施可以提高处方的适当性,生活质量,并减少住院,死亡率和跌倒.
- 需要进一步的大规模,多中心的RCT来证实这些发现.
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