在西班牙患有晚期慢性病的患者中,多中心验证功能衰竭风险方程 (KFRE) 公式
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Beatriz Escamilla-Cabrera1, Marco Montomoli2, Maria Kislikova3
1Servicio de Nefrología, Hospital Universitario de Canarias, Tenerife, Spain; Instituto de Tecnologías Biomédicas, Universidad La Laguna, RICORS2040 (RD24/0004/0025), Tenerife, Spain.
Nefrologia
|June 1, 2025
概括
衰竭风险方程 (KFRE) 有效地预测了西班牙患者慢性病进展到末期病的情况. 四变量KFRE显示出更高的准确性,尽管建议对这一群体进行重新校准.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 慢性病 (CKD) 影响着许多人,因此需要准确的工具来预测进展到末期病 (ESRD).
- 国际验证的功能衰竭风险方程 (KFRE) 估计ESRD风险为2年和5年,但需要在不同人群中进行验证.
- 关于KFRE的预测性能的数据有限,特别是在西班牙患者队列中.
研究的目的:
- 评估KFRE的预测准确性,无论是4变量和8变量配方,对于ESRD的进展.
- 评估KFRE在西班牙晚期CKD患者 (eGFR<30毫升/分钟) 的多中心队列中的实用性.
主要方法:
- 一项多中心,观察性,回顾性研究包括602名EGFR<30毫升/分钟的患者,在2016年至2021年期间进行了跟踪.
- 收集的数据包括临床和人口统计信息.
- 考克斯回归分析和接收器运行特征 (ROC) 曲线被用来评估KFRE的预测能力.
主要成果:
- 研究队列 (60%男性) 患有糖尿病作为CKD的主要病因.
- 在开始替代疗法 (RRT) 的患者中,37%在两年内开始,70%开始血液透析.
- 4个变量KFRE实现了0.7639的曲线下面积 (AUC) (95%CI:0.71-0.81),超过了8个变量模型.
结论:
- 四变量KFRE是预测西班牙人口ESRD进展的有价值工具.
- 虽然证明了效用,但KFRE可能需要重新校准,以提高其对西班牙CKD患者的预测准确度.
- 进一步的验证和重新校准工作是有必要的,以优化KFRE在这个人口群体中的应用.
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