一个缩小的3D-0D流体结构相互作用模型的大动脉,包括小册子曲率
Ivan Fumagalli1, Luca Dede'2, Alfio Quarteroni2,3
1MOX, Dipartimento di Matematica, Politecnico di Milano, piazza Leonardo da Vinci 32, 20133, Milan, Italy. ivan.fumagalli@polimi.it.
Biomechanics and modeling in mechanobiology
|June 1, 2025
概括
我们开发了一种用于大动脉动态的新块参数模型,简化了参数校准以实现高效的血流模拟. 这个模型准确地反映了在生理和静脉条件下的叶片运动和压力变化.
科学领域:
- 计算流体动力学的流体动力学.
- 生物医学工程 生物医学工程
- 心血管模型的建模.
背景情况:
- 精确模拟大动脉动态对于了解心血管健康至关重要.
- 现有的模型经常面临参数校准和计算效率方面的挑战.
- 结合传单弹性和血液流动相互作用是实现现实的建模的关键.
研究的目的:
- 引入一种创新的,高效的动脉动态的一次性参数模型.
- 将这个模型与3D纳维埃-斯托克斯方程配对,以进行全面的血流模拟.
- 为了研究生理和狭窄性大动脉门条件.
主要方法:
- 开发一个简化的一次性参数模型,结合小册子弹性和血流压力.
- 使用电阻沉浸边界方法将模型与3D纳维埃-斯托克斯方程结合起来.
- 通过稳定有限元方法和BDF时间方案对合问题的分离.
主要成果:
- 该模型成功地代表了大动脉的传单运动和血流在上升的大动脉.
- 通过门传单实现了压力跳跃的准确模拟.
- 该系统证明适合分析生理和静脉结构.
结论:
- 拟议的一次性参数模型为大动脉模拟提供了一种高效且易于校准的方法.
- 结合模型准确地捕捉了关键的血液动力学参数和传单动力学.
- 这种方法为研究心血管疾病和治疗效果提供了有价值的工具.
相关概念视频
Fluid Pressure over Curved Plate of Constant Width
1.7K
When a curved plate of constant width is submerged in a liquid, the pressure acting normal to the plate varies continuously both in magnitude and direction. Calculating the magnitude and location of the resultant force at a point is often challenging for such cases. One of the methods to determine the resultant force and its location involves separately calculating the horizontal and vertical components of the resultant force. This complex calculation can be simplified by representing the...
1.7K
Typical Model Studies
448
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
448
Fluid Pressure over Flat Plate of Variable Width
1.8K
When a flat plate is submerged in a fluid, the fluid exerts pressure on the plate. This pressure can lead to many different phenomena, including drag and buoyancy. To understand the behavior of the fluid over a flat plate of variable width, it is essential to analyze the distribution of the pressure exerted.
The pressure distribution on the plate can be calculated by determining the force that acts on a differential area strip of the plate. Thus, the magnitude of the force is equal to the...
The pressure distribution on the plate can be calculated by determining the force that acts on a differential area strip of the plate. Thus, the magnitude of the force is equal to the...
1.8K
Fluid Pressure over Flat Plate of Constant Width
2.2K
When a body is submerged in water, it experiences fluid pressure acting normal on its surface and distributed over its area. For better design structures, it is crucial to determine the magnitude and location of the resultant force acting on the surface. In the case of a rectangular plate of constant width submerged in water, the pressure increases with depth, resulting in a linearly varying trapezoidal pressure distribution from the upper to the lower edge of the plate.
The resultant force...
The resultant force...
2.2K
Aortic Regurgitation I: Introduction
46
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
46


