在患有多病症的老年患者中角膜神经化
Christoph Holtmann1, Mathias Roth1, Kerim Beseoglu2
1Department of Ophthalmology, University Hospital, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Current eye research
|June 1, 2025
概括
角膜神经化 (CN) 改善了神经缩性角膜病变患者的角膜敏感性. 老年,多病症患者需要仔细考虑,因为潜在的风险和并发症.
科学领域:
- 眼科医生 眼科 眼科
- 神经外科 神经外科
- 再生医学是一种再生医学.
背景情况:
- 神经缩性角膜病变 (NK) 显著损害角膜敏感性和眼睛表面的健康.
- 虽然角膜神经化 (CN) 已被确立为先天性低血症,但NK在老年多病患者中更为普遍.
- 这项研究评估了CN在患有并发病的老年患者中的疗效和安全性.
研究的目的:
- 为了评估角膜神经化的结果,在神经缩性角膜病变和显著的并发症的患者.
- 探索使用秒激光技术在创建角膜口袋的神经化.
- 在将CN应用于老年多病患者群体时,确定挑战和考虑因素.
主要方法:
- 五名老年患者 (平均年龄70岁) 的七只眼睛患有NK (由于糖尿病,疹或药物使用) 直接或间接接受了CN.
- 在手术前和后使用Cochet Bonnet美容仪测量角膜敏感度.
- 在一个案例中,使用了 femtosecond 激光来创建宫内角膜口袋.
主要成果:
- 在所有测试区域中,所有手术前的角膜敏感性都不存在 (3 NK 阶段).
- 在CN后3个月,在63%的测试区域中,角膜敏感性得到改善.
- 两只眼睛经历了严重NK的复发,三名患者在随访期间死于并发病.
结论:
- 角膜神经化是一种资源密集的程序,可以增强角膜的灵敏度.
- 用秒激光来检测腹腔内口袋是一种新的方法.
- 在向老年患者提供CN时,仔细考虑长时间的再内尔化时间,角膜穿孔的可能性和并发症至关重要.
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