心血管风险因素影响大脑体积和白质超强度:一个多民族队列研究
Esther M C Vriend1,2, Alexandra de Sitter3, Thomas A Bouwmeester1
1Department of Internal Medicine, Section of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
中年期心血管风险因素会影响大脑健康,导致大脑体积减少,白质超强度 (WMHs) 随着时间的推移增加. 种族差异凸显了个性化脑血管风险评估的必要性.
科学领域:
- 神经学 神经学
- 血管生物学 血管生物学
- 公共卫生 公共卫生
背景情况:
- 脑缩和白质高强度 (WMHs) 是脑血管疾病的关键指标.
- 现有的大部分研究都集中在老年,欧洲血统的人群上.
研究的目的:
- 研究中年人的心血管风险因素与大脑结构之间的联系.
- 在多民族群体中探索这些协会的种族差异.
主要方法:
- 对562名参与者 (摩洛哥人,南亚苏里南人,荷兰人) 的前性研究,随访时间为8.4年.
- 通过3TMRI (MP-RAGE,3D-FLAIR) 使用自动细分来评估大脑和WMH体积.
- 线性回归和相互作用术语分析了关联和种族差异.
主要成果:
- 较高的BMI和糖尿病与较低的大脑体积相关.
- 高血压和先前的心血管疾病与显著更高的WMH体积有关.
- 糖尿病-大脑体积和高血压-WMH相关性在南亚苏里南参与者中最强.
结论:
- 中年心血管风险因素在8年内显著预测大脑体积和WMH变化.
- 观察到的种族差异强调了针对不同人群量身定制的脑血管风险管理策略的必要性.
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