生物聚合物基的水凝珠具有增强的稳定性和pH/离子响应控制释放通过双交联策略
Xiangxiang Lv1,2, Yue Huang3, Mengtao Hu1
1College of Food Science, Southwest University, Chongqing 400715, China.
Biomacromolecules
|June 2, 2025
概括
转胺酶交联增强了凝/酸/碳化纤维素纳米纤维素水凝珠. 这有助于改善物质,并能够精确控制活性物质的释放,如牛血清白蛋白.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 复合生物聚合物水凝珠对受控释放应用有希望.
- 凝 (G),酸盐 (SA) 和碳氧化纤维素纳米纤维素 (cCNF) 为凝配方提供了独特的特性.
- 优化交叉连接对于定制水凝珠的性能至关重要.
研究的目的:
- 为了研究转质氨酶 (TG) 交联时间对G-SA-cCNF水凝珠属性的影响.
- 为了评估水凝珠的结构,胀和受控释放行为.
- 评估pH/离子反应特征和生物活性物质的释放.
主要方法:
- 使用双交联方法与TG和化 (CaCl2) 制备G-SA-cCNF水凝珠.
- 系统变化TG交叉连接时间.
- 水凝珠结构的特征,胀,机械性能,热稳定性和牛血清白蛋白 (BSA) 的受控释放.
- 在模拟的胃和肠液中对反应的评估.
主要成果:
- TG交叉连接显著改善了水凝珠的球状性,水容量,纹理,机械强度和热稳定性.
- 水凝珠显示出明显的pH/离子反应性胀行为,在模拟的胃液中收缩,在模拟的肠液中扩张.
- TG交叉连接创造了一个更密集的网络结构,促进了BSA的受控释放.
- 通过调整TG交联时间来实现释放动态的精确调节.
结论:
- 转胺酶交叉链接是一种有效的策略,可以提高G-SA-cCNF复合液凝珠的性能.
- 开发的水凝珠具有可调节的特性和适合生物活性物质输送的响应释放配置文件.
- 这项研究为设计具有量身定制的释放特征的基于水凝的先进输送系统提供了基础.
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