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Updated: Sep 19, 2025

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
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Published on: June 28, 2019

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通过真菌过氧酶合成19-基亚拉基酸:一个实验和计算研究

Alejandro González-Benjumea1, Mireia Martínez-Sugrañes2,3, Miguel Alcalde4

  • 1Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS), CSIC, Reina Mercedes 10, E-41012, Sevilla, Spain.

ChemSusChem
|June 2, 2025
PubMed
概括

称为非特异性过氧酶 (UPO) 的工程酶现在可以选择性地化阿拉基酸. 一个特定的变体,A77L,显示出高的反抗选择性,用于生产有价值的 (S) - 19 - 基酸.

关键词:
阿拉基酸代谢物的代谢物.计算模拟的计算模拟.通过enantioselective合成进行选择.区域选择性合成不特定的过氧酶酶.

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