检查歧视和加速生物衰老之间的健康风险路径,在老年人的基于人口的样本中
Francisco Rios Casas1,2, Christy L Erving1,2, Mateo P Farina2,3
1Department of Sociology, The University of Texas at Austin, Austin, Texas, USA.
概括
歧视加快了老年人的生物衰老. 健康风险路径显著解释了这种关联,突出了减少健康差异的潜在干预目标.
科学领域:
- 老年学是一门学科.
- 社会流行病学 社会流行病学
- 衰老的生物标志物
背景情况:
- 对老年人来说,歧视是一个重要的压力因素,与残疾和死亡率等不良健康结果有关.
- 歧视与健康之间的联系背后的生物机制尚未完全理解.
- 了解歧视如何影响生物衰老对于制定有针对性的健康干预措施至关重要.
研究的目的:
- 调查日常歧视与老年人加速生物衰老之间的关联.
- 评估健康风险路径在多大程度上调解了歧视和生物衰老之间的关系.
主要方法:
- 利用来自健康和退休研究 (2012-2014) 的数据来研究歧视的频率和归因.
- 使用来自2016年静脉血液研究的22种基于血液的生物标志物的生物年龄估计.
- 采用线性回归和卡尔森,霍尔姆和布林分解方法来分析关联和调解.
主要成果:
- 63%的参与者表示经历过歧视.
- 更高的歧视频率与生物年龄比时间年龄大0.66年相关 (p < .001).
- 对歧视的归因与0.61岁的加速生物年龄有关 (p < .001).
- 健康风险路径解释了约94%的歧视频率和55%的归因相关性.
结论:
- 歧视,无论其归因如何,都会加速生物衰老,并对健康产生负面影响.
- 歧视与加速衰老之间的关联在很大程度上是由健康风险路径介导的.
- 调查结果强调了针对这些途径的干预措施的潜力,以减轻健康不平等,减少歧视对衰老的影响.
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