中年期精神疾病认知衰退的查:使用纵向数据检查临床痴呆症评分的评分
Sean A P Clouston1, Katherine Jonas2, Constantine G Lyketsos3
1Department of Family, Population, and Preventive Medicine/Program in Public Health, Stony Brook University, Stony Brook, NY 11794, United States.
Schizophrenia bulletin
|June 2, 2025
概括
纵向评估显示,精神病中的认知障碍比以前想象的要少. 在25年内,精神分裂症患者的轻度至重度损伤风险增加.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 老年学是一门学科.
背景情况:
- 在精神病中报告的高痴呆症患病率可能会高估稳定的缺陷.
- 区分基线损伤与随后的下降需要纵向数据.
研究的目的:
- 为了确定精神病中的认知障碍是否存在于发病时或随着时间的推移而发展.
- 为了区分稳定的认知缺陷和精神病患者的渐进性衰退.
主要方法:
- 首次入院精神病患者和匹配的对照对象的未来25年随访.
- 临床痴呆症评分 (CDR) 是横截面和纵向分数的框的总和.
- 使用多项逻辑回归估计的多变量调整风险比率 (aRR).
主要成果:
- 纵向评分显著降低了轻度中度 (MI) 和重度损伤 (SI) 的明显患病率.
- 与对照组相比,精神分裂症患者的MI (aRR=4.98) 和SI (aRR=25.98) 风险明显更高.
- 患有精神分裂症的APOE-ε4类同位素显示SI的风险增加.
结论:
- 在纵向评估时,精神病中的认知障碍的流行率较低.
- 观察到的认知和功能衰退对于理解精神病相关的认知障碍至关重要.
- 对于精神病治疗管理来说,CDR得分的变化很重要.
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