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人类乳头瘤病毒感染和宫癌中的微生物组变化:系统性审查和元分析

Wei Zhang^1,2,3, Yan Ge^1,4, Lihe Yao¹

¹The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.

Cancer reports (Hoboken, N.J.)

|June 2, 2025

概括

与健康个体相比,患有人类乳头瘤病毒 (HPV) 感染和宫癌的患者的微生物群多样性有显著差异. 微生物组成的变化与宫病变的严重程度相关,表明微生物环境的演变.

科学领域:

微生物组研究的研究.
妇科瘤学妇科瘤学
传染性疾病传染性疾病.

背景情况:

人类乳头瘤病毒 (HPV) 是导致子宫癌的主要原因.
阴道微生物组的变化与HPV感染和宫癌发生有关.
高通量测序使微生物群落的全面分析成为可能.

研究的目的:

系统地审查和元分析高通量测序研究.
评估HPV感染患者和宫癌患者微生物组α和β多样性的变化.
在HPV感染和宫病变阶段中识别微生物组合的差异.

主要方法:

在PubMed,Embase,Web of Science和Cochrane图书馆的系统文献搜索.
使用随机效应模型对效应大小估计的元分析.
使用Stata MP16软件进行的统计分析.

主要成果:

在HPV感染患者和健康对照人群 (CHAO指数) 之间,微生物多样性显著不同.
亚组分析显示了基于样本区域和测序方法 (香农指数) 的阴道微生物群的显著差异.
像Gardnerella,Prevotella,Porphyromonas和Dialister这样的细菌属在HPV感染和宫病变阶段显示出不同的流行模式.

结论:

简单的HPV感染与多种因素影响的不稳定的微生物多样性有关.
宫微生物组的组成随着宫病变的进展而演变.
微生物变化与宫病变的严重程度相关,突出显示了它们的临床相关性.

关键词:

在HPV病毒中,HPV病毒是病毒.宫癌:子宫癌是一种癌症.高通量测序的测序方法这是一个元分析.我们的微生物群.

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