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Updated: Sep 19, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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异常的异性染色素使慢性淋巴细胞白血病中的免疫反应基因沉默

Olivia M Depies1, Qianqian Guo2, Yuan Gao3

  • 1Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.

Blood neoplasia
|June 2, 2025
PubMed
概括

通过异性染色体标记 (H3K9me3,H3K27me3) 的表观遗传沉默会损害慢性淋巴细胞白血病 (CLL) 和其前体 (MBL) 的免疫基因. 这种沉默在疾病进展和治疗过程中持续存在.

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