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N-Pep-12 改善海马区认知功能,增加神经可塑性和神经发育标记物

Birgit Kastberger¹, Anupam Sah^1,2, Simone B Sartori³

¹EVER Neuro Pharma, Unterach am Attersee, Austria.

Journal of dietary supplements

|June 2, 2025

概括

N-PEP-12,一种神经保护补充剂,在老年小鼠中改善记忆力和大脑健康. 它增强了神经可塑性和神经发生,在老年人群中提供了潜在的认知支持.

科学领域:

神经科学是一个神经科学.
老年学是指老年学的学科.
药理学药理学是指药理学的学科.

背景情况:

老年小鼠 (129S1/SvImJ) 呈现出与年龄相关的认知障碍.
正在探索神经保护性食补充剂以缓解认知衰退.
海马的可塑性和神经发生对于记忆和学习至关重要.

研究的目的:

研究N-PEP-12对老年小鼠认知功能,神经可塑性和神经生成的影响.
确定N-PEP-12是否可以改善记忆保留和增强神经健康.
阐明N-PEP-12认知效应背后的分子机制.

主要方法:

对老年小鼠进行N-PEP-12或Vehicle的慢性使用.
认知表现评估使用指引式恐惧调节 (CFC) 和对象位置记忆 (OLM) 测试.
在体外分析神经可塑性标记物 (NF-L表达,AVP促进物甲基化) 和血脑屏障完整性.

主要成果:

在CFC和OLM测试中,N-PEP-12显著改善了关联和上下文记忆.
在体外研究表明,N-PEP-12增加了NF-L表达,并降低了AVP促进物甲基化.
在氧化应激下,N-PEP-12保持了血脑屏障的完整性,这表明对血管认知能力下降的保护.

结论:

通过增强神经发生和神经可塑性,N-PEP-12促进海马健康.
该补充剂显示了减轻与年龄相关的认知衰退的潜力.
通过神经生物学调制,N-PEP-12是通过神经生物学调制支持老年人群认知功能的有前途的药物.

关键词:

衰老的衰老衰老的衰老在 N-PEP-12 中.认知能力下降认知能力下降认知增强剂是一种认知增强剂.在海马体内,海马体学习学习学习学习学习学习记忆记忆记忆记忆记忆神经发生神经发生.神经可塑性神经可塑性召回召回召回召回召回召回

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