在患有自闭症谱系障碍和注意力缺陷多动障碍的患者中,甲基胺诱导的口吃:一个案例报告
Irem Yildirim1, Ibrahim Adak, Ipek Suzer Gamli
1Department of Child and Adolescent Psychiatry, University of Health Sciences, Erenkoy Mental and Neurological Diseases Research and Training Hospital, Istanbul, Turkey.
在患有自闭症谱系障碍 (ASD) 的儿童中,治疗注意力缺陷多动症 (ADHD) 的甲基 (MPH) 治疗可能会导致口吃. 停止使用MPH解决了口吃,突出了这种ADHD药物的潜在不良影响.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科医生精神病学 儿科医生精神病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是社会沟通缺陷和重复性行为.
- 注意缺陷多动症 (ADHD) 经常与自闭症并发,需要定制的治疗计划.
- 甲基化物 (MPH) 是一线ADHD治疗,但需要考虑ASD儿童的潜在不良影响.
研究的目的:
- 介绍一个患有ASD和ADHD的儿童在开始MPH治疗时发病口的病例.
- 讨论关于MPH和口在这一群体中的关系的文献.
主要方法:
- 一名被诊断为ASD和ADHD的10.5岁男孩接受了OROS MPH的治疗.
- 增加了剂量,并观察到口吃的开始.
- 停止了MPH治疗,并监测了对言语流性的影响.
- 后来MPH被重新引入以证实这种关联.
主要成果:
- 在MPH治疗后,ADHD症状适度改善.
- 在增加MPH剂量后一周出现了口吃,在停止治疗后消失了.
- 在相同的剂量中重新引入MPH导致了口吃的复发.
- 患者的治疗被切换到atomoxetine.
结论:
- MPH和口吃之间的关系没有得到广泛的证据.
- 像口吃这样的不良反应可能会发生在MPH开始或剂量增加时.
- 停止MPH通常会消除这些副作用.
- 需要进一步的研究来了解MPH在ASD和ADHD同时发生的副作用和机制.
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