跨代肥胖 调节肠粘膜免疫力 跨代肥胖
Chen-Ting Hung1, Justin Kern1, Tihana Trsan1
1Department of Pathology and Immunology, Washington University, Saint Louis, Missouri, USA.
概括
孕产妇的肥胖和西方饮食 (WD) 消费会损害后代的肠道免疫力. 然而,后代可以通过采用健康的饮食来逆转帕内斯细胞损失,并保持肠道健康,防止免疫功能障碍.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 美国肥胖率的上升引发了人们对跨世代健康影响的担忧.
- 孕产妇的肥胖可能会对后代的生理功能产生负面影响,包括肠道免疫力.
- 以前的研究将西方饮食 (WD) 消费与肠道免疫细胞密度降低联系起来.
研究的目的:
- 为了调查母亲的西方饮食 (WD) 消费对子女肠道粘膜免疫力的影响.
- 为了确定饮食引起的肠道免疫变化是否在后代中可逆.
- 评估后代的饮食对便微生物组合和感染反应的影响.
主要方法:
- 给小鼠吃高脂肪,高糖的西方饮食 (WD) 或控制饮食.
- 分析了后代肠道免疫细胞群 (帕内斯细胞,内皮性淋巴细胞).
- 在后代中评估了便微生物组的组成和对感染的反应.
- 通过将后代转换为健康饮食来评估饮食诱导的免疫变化的可逆性.
主要成果:
- 雌性WD消费降低了后代的帕内斯细胞和皮内淋巴细胞 (IEL) 密度.
- 在将后代转换为健康饮食时,帕内特细胞损失是可逆的,而IEL损失是不可逆的.
- 后代的食成分确定了便微生物组结构和感染易感性.
- 肥胖母亲的后代可以通过健康饮食来预防肠道免疫力受损.
结论:
- 母亲暴露于WD会影响后代的肠道免疫力,部分可逆性.
- 后代的饮食选择在调节肠道微生物群和免疫反应方面发挥着至关重要的作用.
- 孩子的健康饮食对于预防肠道免疫功能障碍至关重要,即使母亲有肥胖史.
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