在阻塞性睡眠呼吸暂停中,CA125作为生物标志物用于识别疾病严重程度和右心室功能障碍
İlke Erbay1, Rabia Hande Avcı2, Naile Eriş Güdül1
1Department of Cardiology, Bülent Ecevit University Faculty of Medicine, Zonguldak, Türkiye.
Anatolian journal of cardiology
|June 2, 2025
概括
在阻塞性睡眠呼吸暂停 (OSA) 患者中癌症抗原125 (CA125) 水平升高表明疾病严重程度增加和亚临床右室功能障碍. CA125显示为OSA心脏参与的早期生物标志物具有前途.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 生物标志物研究 生物标志物研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与心血管风险增加有关,特别是右心室 (RV) 功能障碍.
- 癌症抗原125 (CA125),一个已知的卵巢癌标志物,正在成为VR功能障碍的潜在指标.
研究的目的:
- 为了比较OSA患者和对照者的CA125水平.
- 评估CA125,OSA严重程度和亚临床RV功能障碍之间的关联.
主要方法:
- 一项涉及60名OSA患者 (严重/不严重) 和60名对照者的横截面研究.
- 测量CA125水平和心声学标志物.
- 使用回归和ROC分析来确定预测因素和诊断性能.
主要成果:
- 严重的OSA患者的CA125水平明显高于非严重和对照组 (P < .001).
- CA125与RV功能标志物 (RV-FAC,TAPSE) 和呼吸暂停-呼吸暂停指数 (AHI) 相相关.
- CA125和TAPSE独立地预测了严重的OSA;CA125显示了VR功能障碍 (AUC=0.857) 和严重的OSA (AUC=0.804) 的强有力的预测值.
结论:
- 升高的CA125水平与OSA严重程度和亚临床VR功能障碍相关.
- CA125可以作为一种有价值的生物标志物,用于检测OSA患者的早期心脏变化.
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