克罗恩病中预期的临时口腔的结果 (肠道研究):国际,多中心,回顾性研究
Claire Perrott1, Giacomo Calini2,3,4, Alice Gori3,4
1Inflammatory Bowel Disease and Ileoanal Pouch Surgery Centre, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
BJS open
|June 2, 2025
概括
许多克罗恩病的临时口腔在18个月内没有逆转. 这使得患者面临着门并发症和长期发病风险的增加.
科学领域:
- 胃肠病学 胃肠病学
- 外科手术的结果
- 炎症性肠道疾病是什么
背景情况:
- 结节性克罗恩病的手术经常需要临时的口腔形成.
- 暂时性口腔可以导致患者的显著发病率和降低生活质量.
研究的目的:
- 评估克罗恩病患者临时口腔的短期 (6个月) 和中期 (18个月) 结果.
- 为了确定门逆转率和门相关的发病率和预测因素.
主要方法:
- 在44个中心 (2017-2020年) 对401名为克罗恩病而经历静脉形成的患者进行了回顾性分析.
- 主要结局:术后6个月和18个月内门逆转的比例.
- 二次结果:逆转的时间,不逆转的原因,以及与静脉口腔相关的发病率.
主要成果:
- 6个月后的口腔逆转率为30.2%,18个月后为56.9%.
- 总体而言,63.3%的临时口腔瘤被逆转,中位数逆转时间为6个月.
- 在29.4%的患者中,发生了与口腔相关的发病率.
结论:
- 在克罗恩氏病患者中,很大一部分临时口腔瘤在18个月内没有逆转.
- 患者面临长期暴露于与静脉口腔相关的风险和并发症.
- 这些发现凸显了需要策略,以优化口腔门的逆转或管理长期口腔门护理.
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