来自黑木的多糖类通过肠道微生物介导的TNF-α/pNF-κB/ICAM-1信号通路减弱结肠炎
Li-Tao Yi1,2,3, Xin-Yu Wang1, Lin Zhou4
1Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province 361021, PR China.
黑木多糖 (PBM) 通过恢复肠道微生物群平衡和减少炎症,有效治疗结肠炎. PBM增强了抗氧化能力,并加强了肠道屏障功能,提供了一种自然的治疗方法.
科学领域:
- * 胃肠道学和免疫学
- * * 自然产品治疗学
- * 微生物组研究
背景情况:
- * 大肠炎涉及免疫系统调节失调和肠道微生物群不平衡.
- *硫酸德克斯 (DSS) 是一种常见的实验性结肠炎诱导剂.
- *正在探索饮食干预措施来管理大肠炎.
研究的目的:
- * 在大肠炎的小鼠模型中研究黑木多糖的治疗潜力.
- *阐明PBM对肠道健康和炎症影响的机制.
主要方法:
- * 在小鼠中诱导大肠炎,使用硫酸德克斯 (DSS).
- * PBM的使用和临床,组织学和生物化学参数的评估.
- *分析肠道微生物组成,短链脂肪酸 (SCFA) 和结肠基因表达 (RNA测序).
- * 便微生物群移植 (FMT) 实验.
主要成果:
- *PBM显著缓解了结肠炎症状,包括体重减轻和组织学损伤.
- *PBM增强了抗氧化能力和密集结蛋白的表达.
- * PBM调节了肠道微生物群,增加了有益的 * Weissella * spp. 和SCFA,同时降低了促炎性标志物.
- * PBM通过调节TNF-α/NF-κB/ICAM-1信号通路来减轻大肠炎.
- * FMT证实了PBM的微生物群依赖的治疗效果.
结论:
- * PBM在小鼠中显示出对DSS诱导的大肠炎的显著治疗效果.
- * PBM通过微生物群调节和调节炎症通路而起作用.
- * PBM代表了一种有前途的天然药物,用于治疗大肠炎和恢复肠道平衡.
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