与多发性硬化症的其他疾病修饰疗法相比,ocrelizumab的持续性:来自德国NeuroTransData注册表的结果
Stefan Braune1, Petra Dirks2, Seya Colloud2
1NeuroTransData, Neuburg an der Donau, Germany. sbraune@neurotransdata.com.
Neurology and therapy
|June 2, 2025
概括
患有复发性复发性多发性硬化症 (RRMS) 的患者在接受奥克雷利祖马布 (OCR) 治疗时,与其他疾病修饰疗法 (DMT) 相比,在两年内治疗持久性更高. 较高的持久性与疾病活动,进展和病假减少相关.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 治疗持续性对于最大限度地提高多发性硬化症 (MS) 的治疗效益至关重要.
- 在复发性复发性多发性硬化症 (RRMS) 中,关于ocrelizumab (OCR) 与其他疾病修饰疗法 (DMT) 的持久性真实世界的数据对于了解治疗结果很重要.
研究的目的:
- 评价和比较与其他DMT在RRMS患者的ocrelizumab (OCR) 的现实世界持久率.
- 调查DMT持续性和临床结果之间的关联,包括复发风险,残疾进展和病假.
主要方法:
- 在2014年1月至2022年4月期间,使用德国NeuroTransData注册表数据对RRMS门诊患者进行了回顾性队列分析.
- 他们将DMT分为奥克雷利祖马布 (OCR),注射,口服,口服治疗高度活性的疾病 (口服HA) 和其他静脉注射 (IV) 治疗.
- 持续性被定义为在开始后两年持续使用DMT,并评估其与复发,3个月确认残疾进展 (3mCDP) 和病假的关联.
主要成果:
- 奥克雷利祖马布 (OCR) 用户的2年持续率最高 (93%),显著超过口服HA (78%),口服 (67%),纳塔利祖马布 (67%) 和注射疗法 (55%).
- 与OCR使用者相比,开始使用其他DMT的患者面临更高的中止风险,主要原因是不良事件,缺乏疗效和患者驱动的因素.
- 与持续使用者相比,不持续使用与复发活动 (RR 2.18),3mCDP (RR 1.52) 和病假 (RR 1.71) 的风险增加有关.
结论:
- 在德国的现实环境中,与其他DMT相比,ocrelizumab (OCR) 与RRMS患者的2年治疗持久性有关.
- 持续的DMT持久性,特别是OCR,与临床疾病活动,残疾进展和工作缺席的风险降低有关.
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