相关实验视频
Updated: Sep 19, 2025

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Oral Health Assessment by Lay Personnel for Older Adults
Published on: February 2, 2020
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一个新的出血风险评分专门针对老年人群中直接口服抗凝剂开发,用于老年人群
Matthieu Piccoli1,2, George Pisica-Donose1,3, Abdelhakim Hacil1,2
1APHP, Centre Université Paris Cité - Geriatrics Department, 54-56 rue PASCAL, Paris 75013, France.
Age and ageing
|June 2, 2025
概括
一个新的出血风险评分,A4C,是为老年患者 (≥80岁) 开发的,这些老年患者患有直接口服抗凝药的心房动. 与现有得分相比,这个得分更好地预测了这个人群中的出血事件.
科学领域:
- 老年医学 老年医学
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 直接口服抗凝剂 (DOAC) 越来越多地用于心房动 (AF) 的老年患者.
- 现有的出血风险评分没有在老年人群中开发或验证.
- 需要一个特定的出血风险评估工具,用于DOAC中老年人.
研究的目的:
- 开发和验证一个新的出血风险评分,适用于80岁及以上的80岁及以上的患者.
- 为了比较新得分的表现与这个特定的人群中现有的验证得分的表现.
主要方法:
- 一项多中心,前性观察性研究包括839名 (≥80岁) 接受里瓦洛克萨班治疗的AF患者,并对其进行1年的跟踪.
- 使用与出血事件相关的临床变量开发了一个预测风险评分 (A4C).
- 研究样本被随机划分为培训和验证组.
主要成果:
- A4C评分包括年龄,贫血,低白血,阿米奥达龙使用和低肌素清除.
- 在老年患者中,A4C评分显示出与HAS-BLED (0.49/0.55),HEMORR2HAGES (0.53/0.50),ATRIA (0.58/0.61) 和RE-LY (0.57/0.54) 相比的优异预测性能 (AUC 0.73/0.66).
- 在80岁以上的患者中,A4C评分≥2的门确定了高出血风险.
结论:
- A4C评分是一个验证的工具,用于评估老年患者 (≥80岁) 的出血风险.
- 这一分数为识别高危人群出血事件的高风险人群提供了更高的准确性.
- A4C评分可以帮助临床医生优化AF的老年人抗凝剂治疗.
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