一个听觉皮质-状回路支持声音触发的时间来预测未来的事件
Harini Suri1, Karla Salgado-Puga1, Yixuan Wang1
1Department of Psychology, University of Michigan, Ann Arbor, Michigan, United States of America.
PLoS biology
|June 2, 2025
概括
小鼠可以使用声音线索预测即将到来的奖励,证明听觉皮层参与定时行动. 这项研究揭示了一种听觉皮质-状回路,这对以声音为导向的时间预测至关重要.
科学领域:
- 神经科学是一个神经科学.
- 听觉感知是一种听觉感知.
- 行为科学 行为科学
背景情况:
- 听觉感知可以根据声音线索预测和定时采取行动.
- 声音引导时间预测的神经机制在很大程度上是未知的.
- 动物使用听觉线索进行狩猎和逃避等行为.
研究的目的:
- 调查声音引导奖励时间预测的神经机制.
- 识别参与处理听觉时间信息的大脑区域.
- 阐明支持声音触发时间行为的电路.
主要方法:
- 在固定头部的小鼠中开发了一种声音触发的奖励时间预测任务.
- 利用听力皮层的失活来评估其因果作用.
- 记录本地场潜力 (LFPs) 来分析神经活动.
- 采用化学遗传学来禁用听觉皮质-状突出.
- 在听觉皮层和后条纹体中同时进行神经记录.
主要成果:
- 鼠标可靠地估计了声音到奖励的间隔,显示了依赖学习的.
- 听觉皮层的失活显著影响了奖励时间预测.
- 听觉皮层反应编码了声音奖励间隔的持续时间.
- 听力皮层的无活化 - 后面的条纹体投影损害了预测.
- 观察到听觉皮层和后条纹体之间的神经活动协调.
结论:
- 听觉皮层在声音引导的奖励时间预测中起着因果作用.
- 听觉皮层活动前性地编码时间间隔.
- 一个听觉皮质-状回路支持声音触发的时间行为.
- 这种电路对于基于听觉线索的预测和启动行动至关重要.
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